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For this reason, parallel resources such as HAMAP (2) and NCBI's ProtClustDB (3) have been developed with the aim of gradually increasing the quality and completeness of functional annotations.
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In general, the quality and completeness of the functional annotation of genomes tend to continuously improve due to the incessant flow of new experimental results and the correction of systematic errors in annotation transfer [ 13].
Thus two control parameters: (a) completeness of design parameters and (b) completeness of functions, have been defined.
Thus, a high correlation coefficient does not necessarily indicate the completeness of the estimated functional repertoire but rather provides a measure of correspondence between the whole metagenome and the 16S rRNA-predicted KO abundances.
Matt Galligan: Readers love the completeness of the functionality as it's seen today.
Given the current state of functional annotation completeness for the GO, it is expected that there are some number of functionally interesting clusters that will be missed, however the number of false positives is expected to be very low with GOSteiner.
For the highest completeness, we employed a network of functional coupling that was drawn up using the methodology of the data integration tool FunCoup [ 13], and then merged with curated pathways from Kyoto Encyclopedia of Genes and Genomes (KEGG), protein complex data from CORUM, and a special network from glioblastoma data.
The completeness of many of these functional sets in this data set is high.
At the time of the home interview, a research assistant reviewed the questionnaire for completeness and administered the Short Test of Functional Health Literacy for Adults.
It takes into account completeness of a conceptual model based upon the concept of functional dependencies.
Although changes to statistical methods or refinements of functional ontologies can improve enrichment performance, annotation completeness and quality is often a dominant factor driving enrichment accuracy and reproducibility.
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