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This leads to a completely rugged landscape, where a single mutation changes the fitness effects of all other possible mutations.
By changing the fraction, r, of the L sites that are replaced, we can tune the amount of ruggedness of the landscape from smooth (r = 0) to completely rugged (r = 1).
At the other extreme, for a completely rugged landscape, every new mutant is assigned an entirely new L-mutant neighborhood with values for the fitness effect of each new mutation re-sampled from p(s).
By adjusting the rules for how the L-mutant neighborhood is chosen, we can tune the fitness landscape from one that is completely smooth to one that is completely rugged.
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Spread offense hysteria has not completely replaced the rugged culture of the SEC, as it has in the Big 12.
All more rugged than I.
Moreover, it is impossible to seal such a long and rugged frontier completely.
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The Associated Press report described a "willing and rugged workman" being "completely outclassed" by a "skinny negro swatter".
A few tiny companies, turning those priorities inside out, are making portables of a completely different sort: cheap, simple, rugged, light, amazingly power-stingy word processors.
Alvhilda leans back on her elbows and turns her face to the sun, seeming completely at one with this rugged old farmhouse and the wild, steep farmland running off the edge of the mountain.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com