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Senescence can occur due to progressive shortening of telomeres, which cannot be completely replicated by canonical DNA polymerases (Harley et al. 1990).
Since the region hosting a polymerase-blocking lesion can be almost completely replicated by an incoming fork starting from an adjacent origin, at low levels of lesions the gaps will accumulate and activate the checkpoint kinases toward the end of S phase.
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Using the proposed simulation methodology, the collapse processes of two bridges are completely replicated.
It is a computerized in vitro study in which clinical condition may not be completely replicated.
Experiment 2A completely replicated Experiment 1.
None of these completely replicates the situation faced by anaesthetists delivering general anaesthesia in a hospital setting.
Then, it was replicated by PDMS in a vacuum oven to completely replicate the extremely concave area on the surface of the photoresist.
Owing to technical- and manpower-based organisational limitations, it was not possible to completely replicate the manual staining methodology adopted initially by the Leeds laboratory in the Cardiff laboratory where an automated staining platform was used.
This was later explained by the so-called end replication problem, the inability of most normal cells to completely replicate linear genomes thus causing progressive shortening of chromosome ends, the telomeres, at every cell division [ 7].
Zattoo completely replicates the traditional TV viewing experience online.
For all its capabilities, the technological platform cannot completely replicate spontaneous on-campus interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com