Due to the maintenance of antibody production by plasma cells, administration of anti-CD20 mAbs almost completely depletes peripheral B cells, but antibody levels are not dramatically reduced [3].
In an animal study (in rats) a polymer tube filled with gel was used for reconnection of completely transected peripheral nerve [ 2].
Furthermore, our studies were performed in wild-type mice, in which body weight and circulating glucose, insulin and lipids were unaltered by exendin-4, together with minimal changes in adipokine expression, suggesting that the reported cardiac effects are likely to be due to direct actions of exendin-4, although it is impossible to completely exclude peripheral effects.
However, the prions accumulated in lymphoid tissues but were almost completely absent in peripheral nervous tissues (Table 2 and Fig. S4).
The enhanced regeneration of sensory neurons by conditioning sciatic nerve lesion was almost completely blocked by peripheral injection of the BDNF antiserum.
They argued that the small amount of normalization that was found with the noise precursor with bilateral presentation was therefore completely due to peripheral auditory compensation effects.
cals5-3 showed a strong defect; unlike wild-type, cals5-3 tetrads completely lacked a peripheral callose layer and had little callose between the microspores (Fig. 4a,b).
In regard to the development of secondary lymphoid organs, it was shown that mice deficient in LTα are completely devoid of peripheral lymphoid tissues, such as Peyer patches (PP) [ 25].
This hypothesis is supported by the observation that OEA anorexiant action is completely absent when peripheral sensory fibers are removed by capsaicin treatment, by surgical dissection or when the drug is injected into the brain ventricles [ 31].
The age related changes throughout human life are also completely different: the peripheral levels show a parabolic peak at the age of about 50 years, while the CSF shows a steady decrease over the successive decades of life, down to less than 25% of peak at the age of 70+ [ 122].
