Plaque reduction neutralization test results showed that anti-pr4 sera failed to completely neutralize infection with the neutralization level varying from 33 to 60%%, and the partial neutralization was cross-reactive among four DENV serotypes (Fig. 6).
Although we used a high dose of neutralizing antibody, it is still possible that we failed to completely neutralize all IL-1 β activity.
The semisynthetically generated chimeric pig-human and human-pig α-chains by exchanging the α1 30 segments of human and pig α-chains have established that the sequence differences of pig α31 141 segment can also completely neutralize the polymerization.
Screening this library to isolate immune-escaping mutants allowed an exhaustive scan of combinations of the 20 natural amino acids at each position and yielded variants that remained infectious when incubated with serum or IVIG concentrations that completely neutralize AAV-2.
As this incident demonstrates, cooking the mushrooms does not completely neutralize the toxic components of Amanita regalis.
And really, the only way to completely neutralize a heavily fortified island, short of nuking it, is to prepare for a bloody amphibious assault, followed by the savage and gruesome work of digging out a deeply entrenched opponent.
