Sentence examples for completely linked with from inspiring English sources
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Sexually antagonistic alleles that are advantageous to males but detrimental to females establish polymorphic equilibria when tightly, but not completely, linked with a male-determining locus [26].
The 142232C>T and 151904T>A were completely or near completely linked with the 142285G>A.
EST-SSR markers are gene-tagged markers directly associated with an expressed gene and, thus, completely linked with putative qualitative or quantitative trait locus alleles.
Functional markers are superior to random DNA markers, such as restriction fragment length polymorphism (RFLP), simple sequence repeat (SSR), and amplified fragment length polymorphism (AFLP), because functional markers are completely linked with trait locus alleles [ 29].
Excluding two O. rufipogon accessions (W1086 and W1092, Additional file 5), the presence of the atp6-orf79 structure was completely linked with the amplification pattern of LD_12, as expected from the closeness of the two regions (Table 4).
To ascertain whether our D' values were consistent with zero recombination, we performed a small scale simulation study for four completely linked microsatellites with the same mutation rates as our sample (see below) and a single UEP.
The class of completely linked markers (with inter-marker distance = 0 cM, including 504 pairs) showed mean r = 0.67, median LD r = 0.92, inter-quartile range from 0.25 to 1.0 and D' = 0.86.
However, on the basis of a small sample size, we only observed a significant increased expression intensity of "completely linked" genes compared with the rest of the genome, with none of these expectations met in "partially sex-linked" genes (table 3).
The SNP rs12865228 within the FREM2 gene on chromosome 13 and its completely linked SNP rs4526895 were associated with a 1.59-fold (95 % CI, 1.21-2.10) incriske in risk.
It should also be kept in mind that accumulation of mutations in cell lines may not be completely linked to growth advantages, as primary tumors rarely are completely pure, but may be contaminated with stromal cells.
