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The first-principles calculations covered 178 phases ranging from pure elements, the ordered B2, B32, B23, B22, hR8, hR7, tI6, C15, and D03 binary phases, two ordered MoNbTaW quaternary phases, and the partially disordered and completely disordered bcc phases.
Data scattered in literature for individual proteins unambiguously show that some proteins involved in human diseases such as cancer, Parkinson's disease and other synucleinopathies, Alzheimer's, prion diseases, diabetes, and cardiovascular disease are either completely disordered or contain long disordered regions.
As many of these proteins are either completely disordered or contain long disordered regions, it would be a clear mistake to analyze them using only the experimental tools developed for the characterization of structured proteins.
It is recognized now that IDPs and hybrid proteins with long IDPRS can adopt a continuum of structural states, such as completely disordered, molten globules, or locally disordered tails and linkers.
In fact, several Archaean domains are completely disordered and only ~2,000 domains are completely devoid disordered regions.
By all Predictors the NTD of EWS consists of large disordered regions, while the CTD is almost completely disordered.
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However, in some IDPs, disorder may play an important functional role without evident disorder to order transition, and in others, ordered regions within proteins that are not completely intrinsically disordered can also undergo regulated unfolding (transition to disorder).
Why is he acting that way?'" "But, of course, in your kidnapper's case, you're trying to get inside a head that's completely jumbled and disordered," I say.
Whereas the knowledge on the propagation of light waves in completely ordered and disordered structures is now rapidly improving, little is known about the behavior of optical waves in the huge intermediate regime between total order and disorder.
Disordered proteins comprise a significant fraction of eukaryotic proteins; some estimates propose as many as 30% of eukaryotic proteins are either completely or partially disordered.
Some IDPs are either fully disordered or completely structured, but most have intrinsically disordered regions (IDRs) that comprise unstructured segments whose amino acid composition prevents autonomous folding [ 4].
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