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Additionally, we find that cascades operating under zero-order ultrasensitivity [17], in which the cascaded signal is either completely activated or not active at all, can serve to slow down signal propagation in a cell, even as the signal is amplified overall.
To summarize these results, we found that the directed mutation of the trypsinogen surface charge led to an almost complete loss of trypsinogen autoactivation, while the enzyme could still be completely activated by its natural activation enzyme human enteropeptidase.
[C8.] Microsoft to Activate XP Firewall Microsoft will begin shipping the consumer and business versions of Windows XP with the protective network firewall completely activated to make PC's less vulnerable to attacks like the malicious software "worm" that has spread over the Internet in recent days.
The Hall effect measurements showed that the hole concentration (1.942 × 1019 cm−3) is almost twice the average Cr concentration (1 × 1019 confirmingfirming that almost all of the Cr atoms were completely activated to the double acceptor state by the laser-doping process without requiring any additional annealing step.
Even in the face of a growing malignancy, one checkpoint molecule that Allison identified -- cytotoxic T-lymphocyte-associated protein-4 -- would prevent the T cells from becoming completely activated.
At 'threshold +10 nA' stimulations, the AIS component was completely activated during the stimulation pulse.
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In this case, a chemosensitizing agent functions by debilitating the ability of a pathogen to completely activate a defense response to an antimicrobial agent [ 29, 30].
In T cells, dominant negative BRAF or MEK inhibition completely abolished activated TCR-driven ERK activation, IL-2 promoter activation and activation of NFAT1 and 2 indicating the importance of MAPK/NFAT signalling in immune cell biology (Tsukamoto et al, 2004).
To completely activate Akt, the serine 473 is crucial.
Despite the marked increase in Igκ recombination, increased IRF4 levels do not completely activate Igκ recombination, which normally increases seven-fold in pre-B cells.
The finding that increased levels of IRF4 alone completely activate Igλ recombination in pro-B cells is striking and implies that IRF4 acts very early in the multistep process of locus activation.
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