One possibility is the French socialist model - gradually reducing working hours and increasing leisure time without completely abolishing the free market.
And the state of Michigan, closely followed by Rhode Island and Wisconsin, led the way in completely abolishing the death penalty in 1846, almost 20 years before Portugal became the first European state to do so.
The second antagonist JNJ-17203212 showed remarkable efficacy in all levels of the TNC at 30 mg/kg, completely abolishing c-fos up-regulation.
The drug response profile demonstrated by lithium and VPA in just attenuating but not completely abolishing manic-like behaviors resembles the efficacy of these medications in treating humans with mania (Greil et al. [1997]; Hartong et al. [2003]).
In addition, more completely abolishing the levels and activity of ER and its co-activators, in combination with selected signal transduction inhibitors or agents blocking the upstream or downstream targets of the ER pathway, may provide a better therapeutic strategy in combating endocrine resistance.
A man who served Congress for more than 59 years says he could fix its broken systems by completely abolishing the Senate.
An even more pronounced phenomenon was observed when IFNγ basic cluster D2 was modified, with a single mutation at position 140 almost completely abolishing LcrV recognition.
In the absence of guanidine most of the mutations appeared to reduce the yield of amyloid, with the A4V mutation completely abolishing amyloid formation (Table S1).
Phenylalanines at positions 559, 571, 755, and 771 reduced the pro-migratory effect of ADAP overexpression without completely abolishing it (Fig. 2C).
However, these phenotypes are not observed in BACE1+/− knockout mice, suggesting that potential mechanism-based side effects might occur only in completely abolishing BACE1 activity but not in partially inhibiting it.
Block of BK channels or deletion of Kcnma1, the gene encoding the pore-forming subunit of the BK channel, increases nighttime firing in SCN neurons, although not completely abolishing the day-night difference in SFR [14], [15].
