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As a positive control, sir3Δ almost completely abolishes cells' ability in heterochromatin silencing (99.8%).
In addition, deletion of the 666WASLWNWFDITNWLWYI682 region completely abolishes the formation of syncytium.
Gene replacement of simReg1 from the S. antibioticus chromosome completely abolishes simocyclinone production indicating that SimReg1 is a key regulator of simocyclinone biosynthesis.
More importantly, inhibition of ERK pathway completely abolishes the CCL2 accumulation in the draining lymph nodes and attenuates anti-tumor activity of DOTAP/E7.
In this way, the DNA aptamer completely abolishes the catalytic activity of the ribozyme, due to the formation of an inactive ribozyme conformation.
Disruption of the C/EBP site decreases, whereas mutation in the Sp1/Egr-1 site completely abolishes DNA-binding and promoter activity.
Strikingly, this mutation completely abolishes kinetic activity.
We therefore conclude that removal of the lipid anchor from PrPΔCD completely abolishes its neurotoxic properties.
A substitution of the amino group on the P1 residue in a peptide completely abolishes the TPPI activity.
IgG purified from the plasma of immune Malian adults almost completely abolishes the adherence of parasitized CB RBCs to MVECs.
This completely abolishes Asterix induction (0/8; Fig. 9 I), unlike control DMSO-soaked beads (4/4; Fig. 9 J).
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