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We use the steady-state assumption to define a transition state complex for the ribosome, coupled with mRNA, tRNA, amino acids and reaction factors, as a subsystem that allows a focus on the completed translational output as a measure of specific properties of the ribosome.
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Although a short poly(A) tail will lead to inefficient translation of an mRNA, it is not sufficient for complete translational repression, as illustrated by the partial polysomal association of histone B4 mRNA and the accumulation of B4 protein in Xenopus oocytes [78,123,124].
This suggests that the inverted results are of good quality for predicting the complete translational ground motions, even though only horizontal components were used in the inversion.
Note that complete translational inhibition is expected to result in a slightly negative value for the normalized translation rate, because GFP levels will actually be lower at the end of the 3 hr measurement interval if no new GFP is synthesized, due to the decay of existing GFP protein.
Fellows are expected to complete a translational research project resulting in a clinical test for patient care during the fellowship.
It is important to not underestimate the complexity and time taken to complete these translational steps.
Overall performance, based on both the number of tasks completed and the total translational distance moved (based on input device movement) within the VE was not hindered for those with low stereo acuity.
Our long-term goal remains to discover clinically relevant alternatives to treat fracture nonunions by completing fundamental and translational preclinical studies that meet biomechanical and biological design criteria.
Study staff assessed error rates by comparison of completed eCODES episodes and any translational errors recorded in the study data system.
Mylea is a translational neuroscientist and completed her Ph.D. Fellowship in Clinical Neuroscience at Stanford School of Medicine.
This highlight the fact that only farnesylation is not sufficient to induce membrane attachment of a chimeric protein and that complete post translational processing is necessary for this purpose.
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