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Among the 35 patients, 30 (85.7%) completed induction chemotherapy.
A total of 70 patients were enrolled between October 2005 and May 2008 and 69 completed induction therapy.
Three patients completed induction docetaxel, cisplatin and 5-fluorouracil (TPF) (two received three cycles, one received four cycles).
A planned interim analysis (after 60 patients had completed Induction 1) revealed an apparent difference in time to recovery from severe neutropenia between the two treatment groups.
The observations of the induction phase were limited to the period between the patient's arrival in the OR to the anesthesia-ready time after completed induction.
At the time of inclusion, all patients had completed induction therapy and were on a maintenance regimen comprised exclusively of MMF and low-dose prednisone.
In order to confirm that pegfilgrastim concentrations were maintained during prolonged neutropenia, a pharmacokinetic substudy was planned for the timepoint when 60 patients had completed Induction 1.
Patients with newly diagnosed multiple myeloma who had completed induction treatment and were scheduled to undergo stem cell mobilisation followed by high dose chemotherapy with autologous stem cell support at Oslo University Hospital, Norway, were eligible for the study.
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Our patient developed progressive dyspnea shortly after completing induction therapy with cyclophosphamide followed by rituximab.
Patients without progressive disease were to have surgery within 6 weeks of completing induction therapy.
After completing induction therapy, patients were randomized to either MR every 3 months for 2 years or observation.
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