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These scores can be summed into an Average Weighted Impact Score (AWI 18, ranging from –9 to 3) by summing all domain weighted impact scores and dividing the result by the number of applicable and completed domains if at least half of the items are applicable and completed.
We recommend that AWI is calculated as the mean of the completed domains with no more than one item of missing data, if the desired alpha level is 0.9, or up to 10 missing values, if the desired alpha level is set at 0.8, which is very acceptable for most research purposes involving group comparisons.
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The availability of such diverse resources offers users a range of diagnostic opportunities, from single functional sites and motifs, to complete domains and autonomous folding units, through to extensive domain- and gene-family hierarchies.
By means of this simple example, it is demonstrated that the power series method with domain partition provides more versatility than the power series approximation on complete domains.
It turns out that pluripotential theory gives a lot of examples of Bergman complete domains.
Only fish and Xenopus have kept the first two C3H complete domains, which are both absent from mammalian sequences.
The liftOver tool was used to convert domains to hg19 build and only complete domains were retained for subsequent analysis (65).
The protein identified as most similar to Not1p has only a partial Not1 domain, while Not2p and Not4p possess complete domains.
By detecting complete domains using global alignment, they identified more than 700 domains homologous to glycoside-hydrolase catalytic corresponding to 45 different carbohydrate-active enzymes (CAZy) families [ 56], including a rich diversity of putative cellulases and hemicellulases.
Overlaying the backbone structures of the four binding helices from both complexes – based on a pair-wise alignment of the complete domains – shows only minor variability in conformation, with the most occurring at the helix spanning residues 216 to 228.
Therefore, one might expect that future Pfam annotations may have an even harder time at identifying complete domains, and thus, should continue to benefit from the extension curation provided by RefProtDom.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com