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We found that cochlear supporting cells re-entered the cell cycle, subsequently proceeded to mitosis and successfully completed division.
We found that in the absence of a functional Min system, FtsA, FtsL and PBP-2B remain associated with completed division sites.
For the sake of clarity, recently completed division sites are denoted as new poles (a membrane stain was used to distinguish ongoing and completed septation), while other poles are referred to as old poles.
However, recently it was shown that the highest chance of minicell formation actually occurs at recently completed division sites, and not at the old poles, challenging the role of the Min system [35].
Positional control of cell division is exerted by two mechanisms: nucleoid occlusion, through Noc, which prevents division through nucleoids, and the Min system, where the combined action of the MinC, D and J proteins prevents formation of the FtsZ ring at cell poles or recently completed division sites.
Taken together, we postulate that the main function of the Min system is to prevent minicell formation adjacent to recently completed division sites by promoting the disassembly of the cytokinetic ring, thereby ensuring that cell division occurs only once per cell cycle.
Similar(52)
Female starfishs produce large numbers of oocytes that are easily isolated; these can be stored in a pre-meiosis phase and stimulated to complete division by the use of 1-methyladenine.
Thus showing that DNA and protein synthesis continued but cells were unable to complete division, since cell number remains constant.
Thus, in a rich medium, the cells grow just a bit longer before they can initiate and complete division [ 25, 26].
Deficiency in or bypass of the decatenation checkpoint can directly result in chromosome instability because cells can complete division in the presence of entangled chromosomes.
Once the engineering work was completed, the division's combat troops participated in several refresher-training courses.
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