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Fibroblasts recruitment at the wound area with reduced infiltrating inflammatory cells enhances wound contraction hence decrease time for complete wound closure [ 31].
Endpoints were wound lengths measured every second day and time to complete wound closure defined as seamless epidermal regeneration and loss of the wound scab.
Primary outcome was rate of complete wound closure.
In both cases, correction was commenced late so as to ensure complete wound healing.
Only the PRP+cells group achieved complete wound closure by 2 weeks.
Time to complete wound closure and 1-year mortality served as secondary outcomes.
After 12 weeks, 56% patients treated with apligraf attained complete wound healing in comparison with 38% of the control group.
A correlation could be observed between the time of complete wound closure and the number of fibroblasts applied.
Complete wound healing was observed with lotion formulation I and II treated rats in 15 days as that of Soframycin ointment.
Prolonged treatment including periodical follow-up and wound dressing was done until complete wound healing was conformed after 11 months postoperatively (Figs. 17, 18, and 19).
Of the six, 3 had lesion sizes ranging from 117 to 390 cm2 needing autologous skin grafts to complete wound cover.
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