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The Regional Co-ordinators of each country will recruit sufficient hospitals to complete recruitment within the trial's timescale.
If the parent wishes to see the GP before consenting, the recruiting clinician will arrange for this to happen, with the parent and child returning to the recruiting clinician afterwards to complete recruitment.
Sixty-two centres would need to recruit 0.5 subjects per week to complete recruitment in four years.
This trial began recruiting patients in June 2012 and shall complete recruitment in December 2012.
The impact of this increased recruitment rate has been that even with increases in trial size, the time taken to complete recruitment has fallen, such that the median duration of trials that recruited at least 90% of the target had fallen from 7.2 years (1971 1975) to 2.7 years (1996 2000).
Through a coordinated approach of developing and refining recruitment strategies and materials, sites were able to adapt their original strategies and complete recruitment ahead of schedule.
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The study completed recruitment in 2008 and all recruits have consented to the use of their data in research.
The earliest cohort study recruited patients starting in 1978 and latest completed recruitment in 2007, with mean reported follow-up ranging from 6 to 18.8 years.
Selection bias resulting from recruiting participants after cluster allocation has been revealed will be avoided by completing recruitment and screening assessment prior to randomisation.
Ninety-five patients completed recruitment and are included in analysis.
Mild ARDS patients nearly completed recruitment at approximately 15 cmH2O transpulmonary pressure while in moderate and severe ARDS recruitment continues up to 26 cmH2O transpulmonary pressure.
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