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Remarkably, whereas prostratin-induced IκBα degradation was followed by its reappearance after a 1 h treatment (Figure 5B, lane 6), complete reappearance of cytoplasmic IκBα at this time point was not detected after the combined treatment prostratin+VPA (Figure 5B, lane 8).
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Costimulation with UVB, however, results in complete inhibition of IκBα reappearance and NFκB termination.
A relapse was considered to be either a positive blood culture two months to one year after completing the treatment or the reappearance of compatible symptoms not otherwise explained together with an increase in the previous serological titers.
Such residual lesions, which contained 'disappeared' tumours, are at risk of reappearance as a radiological complete response is not a guarantee of cure (Benoist et al, 2006).
All patients failing treatment, defined as reappearance of parasitemia after its initial complete clearance or failure of complete clearance within 28 days, were retreated whether they became symptomatic or not and after samples had been obtained for microscopy and PCR analysis.
5 "Recurrent nodal disease" was defined as reappearance of lymphadenopathy after initial complete regression of nodal disease.
Then the secrecy surrounding Clooney's reappearance on the show was so complete that even his agent and top executives of NBC had no idea about it until they saw it on their TV screens.
Subsequent IκBα phosphorylation and proteasomal degradation is completed at the latest after 15 min. Reappearance of IκBα after 90 min perfectly matches dephosphorylation of IKKβ and disappearance of NFκB from the nucleus.
Recurrence was defined as disease reappearance 3 months or more after completion of primary treatment in a patient considered to be in complete remission.
Even the reappearance of Hammond on Saturday night as Bill Clinton (complete with a sax solo) couldn't upstage McKinnon's preternatural impersonation.
Although microbiological examination was not performed at the time the patient presented with tonsillitis, the reappearance of sore throat within 4 days after completing a 5-day antibiotic therapy with amoxicillin/clavulanic acid and the presence of GAS in throat swab cultures at the time she presented with PTA, strongly suggest GAS aetiology of antecedent tonsillitis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com