Sentence examples for complete loss of function from inspiring English sources

Incorporation of an unpreferred codon is unlikely to be functionally equivalent to a complete loss of function.

Moreover, unlike many polymorphisms, the ACTN3 R577X polymorphism is a functional polymorphism, with the XX genotype resulting in complete loss of function.

Thus the creation of deletion should be considered to generate complete loss of function mutants.

This lack of ligand binding function confirms that oscillator is a complete loss of function allele.

Even though all beta cell types had a similar number of granules, complete loss of function of the GCK gene was associated with decreased beta-cell production.

"Sometimes the cord can go into spinal shock and it might appear that he has complete loss of function, but you can't be sure until the period of spinal shock is over," he said.

So far, attempts to uncover PU.1's role in HSC biology have failed because of the technical limitations of complete loss-of-function models.

Hence, inhibition of translation is transient and may not result in a complete loss-of-function.

To test theses hypotheses, we generated and analyzed phenotypes associated with a complete loss-of-function allele of Toll-9.

Alternatively, it is also possible that the Chk1D469G mutant is simply a partial, rather than complete, loss-of-function mutant.

In order to study Toll-9 receptor function, we generated a complete loss-of-function allele by targeted homologous recombination [44].