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Although one small (26 bp) LKB1 deletion representing a complete loss-of-function was identified by sequencing (Table S1, Figure 1A), larger deletions would have been missed.
Furthermore, complete loss of PTEN is thought to be a late event and can be considered a critical landmark for progression to aggressive and invasive disease.
Due to its crucial function, complete loss of EXOSC3 is likely to be lethal.
Because the proteins in early embryos are predominantly maternally derived, and the complete loss of BicD is lethal, it has not been possible to generate embryos entirely lacking in BicD.
Given the numerous requirements for cilia in diverse cellular processes, it is unsurprising that complete loss of cilia is devastating to a mouse or a human being.
Further reductions in PDE could affect photoreceptor survival and be irreversible, as complete loss of PDE is toxic to photoreceptors (43).
In humans, Ncf1 is redundant and a complete loss of function is associated with chronic granulomatous disease that has increased susceptibility to microbial infections.
Dear editor, A patient with sudden complete loss of vision is presented, which ultimately turned out to be caused by a pituitary adenoma coincidentally infected with MRSA.
Since a complete loss of phospholabeling was not observed, the presence of additional phosphorylatable sites is proposed.
This suggests that a complete loss of MPI is not compatible with survival, whereas heterozygosity for MPI is well tolerated.
Complete loss of DHRS7 was never observed in normal prostate tissue samples, while this was the case in 6.1% of PCa samples.
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