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Transient gene expression assays of increasing concentrations of plasmids encoding WT or MT RSPO1 showed a modest but significant activation of the TOPFLASH reporter vector for the WT (maximal 1.8-fold) and a complete lack of activity for the p.Ile32_Ile95del mutant plasmid (Fig. 3A).
This complete lack of activity on the Gram-negative organisms is most likely due to the protective nature of the outer membrane of their cell walls.
Comparison of the dose response curve for Bcl2-cb5 with the control demonstrates a complete lack of activity for Bcl2-cb5 at every concentration of doxorubicin tested.
No fluorescence was seen in any cells, indicating complete lack of activity of Moocci.Mesp enhancer in wild-type C. intestinalis embryos.
The complete lack of activity of norbinaltorphimine against T. rucei suggests that possible CNS side effects of a treatment based on -U50,488 could be reduced by co-administration of a κ-opioid antagonist.
Of added interest is the fact that, despite a complete lack of activity and, most importantly, significantly impaired iron binding as judged by ITC, strong density in the 2 Fo – Fc map corresponding to bound metal is visible in the active site.
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However, a near-complete lack of activity will not allow you to flex your cognitive muscles.
The naturally occurring splice variant lacking exon 4, AID-Δex4 (AY536517), encodes a C-terminally truncated product, which, in contrast to the full-length transcript, is characterized by the complete lack of CSR activity, while showing hyper-SHM activity [ 20].
EspP proteins of the respective subtypes produced by STEC strains displayed complete lack of proteolytic activity [16], whereas mutant Y313F/N316K demonstrated reduction of activity of approximately 50%.
It is noteworthy that most of Nipped-AKG10162 and Psc EY06547 flies displayed a significantly reduced or complete lack of locomotor activity during the dark phase but became active again in the light phase (Additional file 1: Figure S5), representing prolonged uninterrupted bouts of sleep.
Furthermore, the high enzymatic activity observed for GrB generated upon fur cleavage and the complete lack of enzymatic activity of GrB generated upon processing of the furS site indicate that cleavage of the MBP fusion proteins did not occur randomly but at the predicted positions.
More suggestions(16)
total lack of activity
complete lack of action
term lack of activity
complete lack of transparency
complete lack of conscience
complete lack of self-consciousness
complete lack of direction
complete lack of commerciality
complete lack of intellect
complete lack of responsibility
complete lack of reference
complete lack of cynicism
complete lack of faith
complete lack of superstar
complete lack of suspense
complete attenuation of activity
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com