Additionally, CD28 and other less well-investigated costimulatory pathways must be activated to ensure a complete and efficacious T-cell activation, collectively designated signal II [ 18, 19].
The most efficacious ADC showed complete tumor regression and 10/10 tumor free survivors at a single 0.5 mg/kg dose.
Most respondents claimed that their herbal remedies were efficacious and produced complete healing without adverse effects.
Pulmonary metastasectomy has been shown to be efficacious in that complete macroscopic clearance has been achieved; in appropriately selected cases, R0 resection of all known pulmonary metastases can be consistently accomplished.
RAVE's primary results demonstrated that rituximab was non-inferior to cyclophosphamide for the induction of complete remission and was more efficacious than cyclophosphamide for the induction of remission in patients with relapsing disease [ 2].
Toxicity profiles of FOLFOX and FOLFIRI (Andre et al, 2004; O'Connell, 2004; Allegra and Sargent, 2005) may reduce the completion of these treatments, but fewer cycles of these regimes may be as efficacious as the completed Mayo regime.
Prior studies have shown that the procedure is safe and efficacious in laboratory animals and that complete cell death, as assessed by tetrazollium staining, is achieved in the laser treated area.
Our simulations predicted that the two dosing regimens (10 mg q4wk and 10 mg q6wk) selected for the phase III studies are expected to be efficacious and able to achieve near-complete target suppression in the vitreous humor.
The constructed model provided a prediction of target occupancy in ocular tissues and supported that the two dosing regimens (10 mg q4w and 10 mg q6w) selected for the phase III studies are expected to be efficacious and able to achieve near-complete target engagement in the vitreous humor.
The humanized version of Sphingomab, sonepcizumab/ASONEP (Lpath), has recently completed Phase I clinical trials in cancer, and will be advanced into Phase II safety and efficacy trials, which might be efficacious for controlling tumour growth and metastasis.
