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Subsequently, a complete dose response of RDX was tested in the [S]- t-butylbicyclophosphoorothionate ([S]-TBPS) convulsant site assay (catalog no. 226830) using picrotoxin as standard; this assay is based on the method of Maksay (1993).
A dose response analysis for OdDHL (8) is shown in Figure 2A, and assay data at low and high concentrations for all 17 compounds are shown in Figure 2B (for complete dose response analyses, see Supporting Information Figure 1).
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We did not, however, perform a complete dose-response study to determine which dose(s) of the 5-HT4 agonist permit(s) to observe an optimal augmentation.
Such concentrations of Ag-EN and Ag+ were chosen to ensure the observation of complete dose-response curves based on the results of the preliminary experiments.
Third, our study had a relatively small sample size compared to a complete dose-response study.
A complete dose-response analysis of rapamycin in combination with IR is shown in Supplementary Data (Supplementary Figure S3).
Complete dose-response curves were determined for cells in the G1, S and G2M cell cycle phases.
In certain domains, computational modelling requirements call for improved data acquisition and experimental design approaches (driven, for example, by the need for complete dose-response curve characterization, or species-specific values of biological parameters).
The importance of the complete dose-response curve in the tissue transport studies, as opposed to the measurements at a single concentration, for the characterization of relative transport rates of individual acids was noted.
Owing to its hydrophobic nature, it was not possible to obtain a sufficient number of bioassay data points to prepare a complete dose-response curve, but the ChM-I cyclic peptide was clearly bioactive (Fig. 6A), with an estimated ID50 value of 2 μM.
The equilibrium spectrum [9], [19] for the steady-state pupil constriction (n = 4 subjects) is based on measures obtained in each subject at each of the 11 different pre-exposition wavelengths and corrected according to the complete irradiance dose response curves of the 2 subjects recorded in the initial experiments to obtain the half saturation values.
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