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"The work is not complete, and major political issues need to be decided on.
Complete and major control (less than or equal to 2 emetic episodes) of acute emesis was achieved in 74% of patients in group I, 78% in group II and 74% in group III.
In a retrospective analysis of 115 PC patients treated with preoperative irinotecan or oxaliplatin based chemotherapy followed by CRS and IPC, Passot and coworkers demonstrated a complete and major pathological response rate of the peritoneal disease in 10 % and 20%% of patients respectively [ 48].
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It is important to note that the best category of tumour response slightly differs between classifications, for example, the best category according to Rubbia-Brandt et al (2007) includes complete (TRG1) and major response (TRG2), while the best tumour response according to Blazer et al (2008) only consists of complete response.
Imatinib therapy induces high rates of complete cytogenetic and major molecular responses, and improves survival in CML.
In interviews it became apparent that the definition of a 'ward closure' could range from complete closure and major refurbishment, especially if there was evidence of a persistent problem, to partial closure of consecutive bays.
Furthermore, recent evidence suggests that steady-state trough imatinib plasma concentration (TPC) at initiation of therapy is a significant predictor of complete cytogenetic and major molecular responses (Larson et al, 2008).
Similar to our case, treatment with imatinib did not lead to improvement in constitutional symptoms or splenomegaly in either patient, although they both achieved complete cytogenetic and major molecular responses of their CML.
Moreover, the design of our study wherein AUC derived from sparse measurements were used as an index of exposure may have prevented us from observing similar results as in the IRIS study (steady-state imatinib TPC at initiation of therapy in patients on 400 mg QD predicts long-term complete cytogenetic and major molecular responses) (Larson et al, 2008).
Although Dr. Visotsky's project took several years to complete, Dr. Hansell said, by the early 1980's the shift to local care in Illinois was mostly complete, and the major role played by state hospitals had diminished.
Twenty-nine patients were evaluated cytogenetically: 13 demonstrated cytogenetic improvement, including five complete and four major cytogenetic responses.
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