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This was a prespecified secondary investigation of the original CLUE study (reported elsewhere 9), designed before statistical analysis was performed, but after the database was complete and locked.
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The allocation sequence was not available to any member of the research team until databases had been completed and locked.
Capturing and archiving a study snapshot at a particular point in time can also provide traceability and reproducibility when researchers publish on intermediate results before a study has completed and locked.
Once complete, Voyager rolled back and locked on to its guide star, Alpha Centauri.
Data were unblinded only when the trial was completed and the data verified and locked.
In this case the fault has two states: sudden slip during earthquakes, and complete locking between them, in a process called stick slip, and such faults are described as strongly coupled.
It took the Yorkshire-based graphic artist (whose real name is Steve Beaumont) eight months to complete them, "locked away in a room with no windows and just the music and videos of Nirvana plus a copy of Kurt's journals for company".
Our concept of the digital SQUID consists of a double relaxation oscillation SQUID (DROS) with the complete flux locked loop (FLL) electronics on one single chip.
Comparing this with the MDR estimated from real geodetic data, moderate and almost complete locking of the plate interface was confirmed for the seismogenic regions off Tohoku and Nankai, respectively.
Outcome measures were not problematic for participants to complete, however, the project manager had to remind participants to complete and return to the locked box.
The sequence and decode of treatment allocations were concealed until all interventions were assigned and recruitment, data collection and all other trial-related assessments were completed and study files locked.
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