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b The path length can be easily determined by counting the number of edges that must be traversed to complete a pathway from the starting (green) node to the target (red) node.
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This is directly analogous to the number of enzymatic steps that must be engineered to complete a biosynthetic pathway.
We aimed to explore whether a strong signal is required to enter and complete a developmental pathway, by using meiosis in budding yeast as a model.
Unlike most ion channels that have varying degrees of rotational symmetry around a central aqueous pore, CLC proteins are dimers, with each subunit containing a complete conduction pathway, a protopore (7).
Indeed, it has been suggested that although a complete pathway for a particular substrate may not exist in a single organism, partial and complementary pathway segments may exist in different organisms [32].
The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.
While acquisition occurs without much intermediate variation, decay from a complete pathway takes a different route, visiting these intermediate states.
A complete signaling pathway involving a bacteria STK remains to be described, but one may anticipate that some STKs are important or even essential in regulating bacterial activities.
In this paper a complete pathway to construct a constitutive model well suited for finite element analysis of viscoelastic media undergoing large deformation and damage is described.
Here, pathways are not limited to those that exist within a single organism, but can contain any enzymatic reactions from multiple organisms to complete a novel, heterologous pathway.
Increasing the copy number of genes in a complete pathway was employed as a strategy to increase the in vivo flux through the tryptophan biosynthesis pathway via genetic manipulations.
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