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As we faced the limitation of a direct comparison due to the different nature of samples (single cell type neuron versus all cells types frontal cortex), we decided to make the analyses using gene co-expression network complemented with the exploration of biological processes.
We complemented our investigation with the exploration of core clock proteins in striatum, the fundamental brain structure implicated for timing in the seconds-to-minutes range12.
While all these markers can be used to complement current markers [42], the exploration of a large panel of protein markers to improve the differential diagnosis may rapidly become more cumbersome and less relevant than the study of the expression profile of selected genes, especially in the case of suspicious nodular thyroid lesions.
Experimental structural biology and homology modeling thereby complement each other in the exploration of the protein structure space and as a result structural coverage to a large extent is now available for the proteomes of many model organisms such as E scherichia coli (7) or T hermotoga maritima (8).
The unique contents of TIPdb-3D could complement other databases and enable the exploration of chemical space diversity.
The new library could be used not only for the selection of such dAbs thus complementing existing libraries but also as a research tool for the exploration of the mechanisms determining folding and stability of human antibody domains.
Here, the mining of publicly available microbial genomic data proved to be a useful complement to these approaches as it enables the exploration of host-linked viral diversity.
The great potential of graphene has stimulated a lot of interest in the exploration of other layered 2D nanomaterials, which can complement the requirements associated with graphene.
The exploration of grief also won plaudits.
The exploration of the ocean depths will happen just like the exploration of Mars.
This allows the exploration of other events.
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