Diseases involving loss-of-function of p300/CBP could theoretically be treated using compounds that chemically complement point mutations in the acetyltransferase active site, stimulate p300/CBP activity, or inhibit deacetylase activity.
Pathway analysis can complement point-wise single nucleotide polymorphism (SNP) analysis in exploring genomewide association study (GWAS) data to identify specific disease-associated genes that can be candidate causal genes.
It is increasingly recognized that pathway analysis can complement point-wise single nucleotide polymorphism (SNP) analysis in exploring genomewide association study (GWAS) data, through the identification of pathways and SNPs (genes) associated with the tested phenotype.
In contrast, mice inoculated with the nleL mutant or the non-complementing point mutant NleLC753S gained weight (5 % and 4, respectively) and were not significantly different from uninoculated mice throughout the study.
This study confirms the existence of a parallel increase between the expression of Bcl-2 and Bax in GBM tumors, as previously described by Martin et al. Here, we complement this point by noting that the expression level of Bcl-w also correlates with the expression level of Bax and Bcl-2.
In the situation of statistically non-significant study results, just the absolute and relative frequencies should be presented complemented by point and interval estimates of a relation effect measure, which can be interpreted easily in all situations, e.g. the risk ratio.
Quotes should be used sparingly and must thoroughly complement the point they are being used to exemplify/justify.
The talk has been that the European champions had not met any serious opposition, yet raiding parties to north London have now returned with a full complement of points from Arsenal and Tottenham.
To understand Hz formation in the gut lumen of R. prolixus, the present study provided important data to complement the points discussed in the review by Egan [30].
Since rain gauge measurements have relatively high precipitation accuracy at the gauge station point, complementing the TRMM satellite data with rain gauge measurements through a bias correction method and using it as an input to drive distributed hydrological model could enhance the runoff simulation precision.
