One of these, the staphylococcal complement inhibitor (SCIN), acts at the level of the C3 convertase (C3bBb) and impairs downstream complement function by trapping the convertase in a stable but inactive state.
The functional diversity provided by disordered regions is believed to complement functions of ordered protein regions by protein-protein interactions [41].
All it takes is complementing the function above with interaction terms of the type γ k. (b k y i ).
Interestingly, VirF is not required for infection of some plants and it is thought that host F-box proteins can functionally complement VirF function (Zaltsman et al., 2010).
The high frequency of MBL deficiency and functional defects [5], [9] makes MBL mediated complement function assays unsuitable for elucidation of deficiencies downstream of MBL itself.
An overview of complement function is provided in order to understand the underlying genomic landscape.
To exclude that complement activity played a role, whole blood circulation experiments were also conducted at 10 U/ml of soluble heparin, a concentration which inhibited complement function.
Petry, F., Botto, M., Holtappels, R., Walport, M. J. & Loos, M. Reconstitution of the complement function in C1q-deficient (C1qa−/−) mice with wild-type bone marrow cells.
To preserve complement function while prevent clotting, blood from healthy donors was treated with a low dose (1 U/ml) of soluble heparin and was kept in rotation in a Corline heparin inner surface tubing system.
