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In the following, we will use entrepreneurs A and B as the main cases and entrepreneurs C and D as complementing, control cases.
In addition to complementing control region phylogenies, analysis of mtDNA coding regions may help resolve geographical distribution patterns because coding regions of the mtDNA are under strong selection due to their fundamental role in energy and heat production [ 7, 8].
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Vaccinia virus complement control protein (VCP) inhibits both pathways of complement activation through binding the third and fourth components.
The putative AmphiCFH protein possessed the characteristic of the CFH protein family, including typical CCP (complement control protein) domain.
The virus produced and transmitted within the same host species would be protected since complement control proteins are highly species specific.
The vaccinia virus complement control protein (VCP) is involved in modulating the host inflammatory response by blocking both pathways of complement activity through its ability to bind C3b and C4b.
The 155-kDa plasma glycoprotein factor H (FH), which consists of 20 complement control protein (CCP) modules, protects self-tissue but not foreign organisms from damage by the complement cascade.
Vaccinia virus complement control protein (VCP) possesses the ability to inhibit both classical and alternative pathways of complement activation, as well as bind to heparin or heparan sulfate proteoglycans, making it a unique multifunctional protein with therapeutic potential.
The poxviral complement control protein VCP (vaccinia virus complement control protein) can bind to complement components C3b and C4b, respectively, thereby inactivating complement components or blocking the formation of the C3 convertase complex [8].
Extracellular vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope [9].
The KSHV complement control protein (KCP) accelerates the decay of classical C3 convertase and induces the degradation of activated complement factors C4b and C3b [22].
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