The differential efficacies of SRT and ERT in the different tissues indicate that the combination approach is both additive and complementary suggesting the possibility of an improved therapeutic paradigm in the management of Fabry disease.
For example, over expression of LEAFY generally results in early flowering [ 48, 49] and cases in which LEAFY is present in duplicate (typically in recent polyploids), expression patterns are typically complementary, suggesting that subfunctionalization may be necessary for the maintenance of both loci [ 50, 51].
Indeed, as underlined by Kumar and Yarus [ 45], four of the central reactions involved in protein biosynthesis are catalyzed by ribozymes, and their complementary nature suggests suggestive that they may have first appeared in the RNA world.
Insight into the mechanism through which naPINK1 may regulate svPINK1 also comes from the observation that naPINK1 appears only to influence the abundance of the near full length complementary cis transcribed svPINK1 sequence (only 52 bases of the 5' end of svPINK1 are non-complementary) suggesting a potential role for dsRNA mediated stabilization.
Complementary analysis suggests that self-assessed relative poverty (as measured by comparison to other households in the community) is a more important mediator of program effects on happiness than absolute poverty (as measured by household consumption expenditures).
This strikingly complementary pattern suggests a reciprocal interrelationship between the balance of pro- and anti-apoptotic genes in ES cells and their differentiated progeny.
A complementary teleology suggests that maintaining high rates of glycolysis is required to reconfigure metabolic pathway fluxes to achieve more efficient anabolic metabolism and cell-autonomous growth.
Consistent with prior observations [ 22, 60], WKY's different thresholds in the complementary tasks suggests that this strain may not provide consistent baseline levels of response inhibition required for the assessment for impulsivity in SHR.
Recent complementary investigation suggests that increased FF AMH in women with PCOS may have harmful consequences on oocyte quality and maturation, via an unclear molecular mechanism, but does not have an effect on pregnancy rates (Desforges-Bullet et al., 2010).
