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Caillois has described at length the social mechanism of nonliterate societies, in which the group is divided into two complementary subgroups (moieties), and has interpreted the tabus and the necessary interrelationship of the moieties as expressions of sacredness.
ACVR2 loss and pSMAD2 loss appear to occur in complementary subgroups, suggesting more than one target to inactivating activin signaling in MSS colon cancers.
The C-statistic varied widely across complementary subgroups (Table 3).
Across complementary subgroups, associations of CRP with cardiovascular mortality by diabetes status always were similar (all P ≥ 0.09 for the three-way interaction tests).
The small number of patients with other histologies and who were never smokers did not allow meaningful survival analysis in these complementary subgroups.
UBT Δδ value thresholds were calculated in random subgroups and evaluated in complementary subgroups using logistic regressions on reference histology or bimodal distribution analyses of Δδ values from UBTs alone.
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Complementary subgroup analyses are done for gender, socioeconomic status and ethnicity.
However, it is unclear why the higher dose was more effective in one subgroup, and the lower dose apparently better in the complementary subgroup.
The demographic characteristics and treatment history of the target population were very similar to those of the patients not eligible for this post hoc subgroup analysis (complementary subgroup) and to those of the total population.
We compared the performance of complementary subgroup-specific classifiers with a single global classifier that was constructed using feature selection and operating point selection as described above, but without partitioning the data set.
The complementary subgroup (i.e. patients below high drinking risk level at screening or randomization) substantially reduced the number of HDDs from screening to randomization, with only a minor reduction from randomization to Month 6 and no differences between the treatment groups (Supplementary material, Fig. S2).
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