Sentence examples for complementary determining from inspiring English sources

complementary determining region 3. recombination signal sequence.

In particular, α14 inserts into the cavity formed by two common complementary determining regions (CDRs) in the heavy chain (Figs. 4B and 5).

Antibody molecules bind to antigen with six complementary determining region (CDR) loops, three of which are located on each variable heavy (VH) and light (VL) chains.

The interaction surface on JL2 has five of the six common complementary determining regions (CDRs): HCDR1 (residues 28 32), HCDR2 (residues 54 55), HCDR3 (residues 100 107), LCDR1 (residues 31 32), and LCDR2 (residues 50 55) (Figs. 4C and 5).

Specifically, affinity enhancement can be tailored to the target-binding surface, typically the complementary determining region (CDR) loops in antibodies, whereas enhanced stability, expression or catalytic properties can be affected by selected changes to the core protein scaffold.

Complementary determining region (CDR) 3 length spectratype analysis of 19 TCR Vβ families was used to identify the relative frequency of T populations in PLN of 4 and 10 week old NOD mice and mice at T1D onset.

Induction of Trp oxidation in the complementary-determining regions (CDRs) of a monoclonal antibody by photooxidation resulted in a progressive loss of target binding and biological activity [6].

The major differences between the amino-acid sequences of the three clones were concentrated in the hypervariable complementary-determining regions, CDR2 and CDR3, of the VH.

This mAb contains murine complementary-determining regions (CDR) anti-p185 and human framework regions and as other recombinant proteins is susceptible to undergoing posttranslational modifications.

Determination of several structures of Rab proteins with their regulators or effectors revealed that in such interactions participate switch and interswitch regions, RabSF1, -SF3 motifs and CDRs (complementary-determining regions, overlapping RabSF1, -SF3 and -SF4 motifs) [ 115- 119].

Because the mouse anti-HM1.24 mAb exerted a marked anti-MM activity through the operation of ADCC and CDC machineries, we have established a humanized anti-HM1.24 mAb (AHM, IgG1- κ) by grafting the complementary-determining regions [ 52, 53].