Exact(1)
Among 4 mutated residues with vdW forces, 3 residues (75%, 2 Phe residues and 1 Trp residue) and their complementary contact residues (2 Tyr residues and 2 Trp residues) form the stack force interactions.
Similar(58)
In addition to shape and charge complementary, contacts from the arginine and aspartic acid residues within motifs 1 and 2 provide specificity for recognition of guanine cyclic nucleotides; the multiple interactions effectively exclude binding to adenine cyclic nucleotides.
The model generated by BD and MD depicted in Figure 3 shows several hydrophobic and complementary electrostatic contacts that are likely important for complex formation.
Due to the context in which we received these data, we were not able to obtain additional documentation, access the original or complementary data, or contact company personnel knowledgeable about the data.
Services included primary and secondary healthcare contacts, complementary healthcare, social care, medication and tests/investigations. Additionally, patients were asked whether their contacts with professionals were due specifically to fatigue although all contacts were considered in the analysis.
Services included primary and secondary healthcare contacts, complementary healthcare, social care and medication (only anti-depressant, anti-anxiety and sleeping medication).
Two complementary monitoring instruments for contact persons were used: active follow-up with daily telephone contact and a self-administered monitoring questionnaire.
Improvements in information technology have paradoxically led to more demand for complementary face-to-face contact.
The pioneering work of Clackson and Wells has shown that only a small and complementary set of cooperative contact residues, termed "hot spots" maintains the binding affinity [ 8].
MOMP is regulated by the strictly binary and competing protein-protein interactions that can occur between the pro-apoptotic and the pro-survival family members, in which the hydrophobic face of the exposed BH3 helix of activated pro-apoptotic members makes contact with complementary binding pockets (P1-P4) located in a surface groove of the pro-survival members.
Comparison of the different AChBP conotoxin complexes reinforces the notion that α-conotoxins can use different surface contacts to interact with the principal binding site, whereas the surface area that contacts the complementary face of the binding site remains relatively conserved.
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