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Possible complementary charge patterns on the amino acid sequences of several mammalian decorons were found; two motifs with opposite orientations: 243-RELH-246 on LRR repeat 10, and 101-KLER-104 on the LRR repeat 3 4 boundary [24], repeat numbering as in [25], where the uncharged, structural leucine residues would be equivalent spacers to the glycine residues in the collagen pattern.
Complementary charge interactions between acidic phospholipids and the basic effector domains are required for high affinity binding.
The results show that both models have extended regions of complementary charge on the predicted interacting surfaces.
In both the no-nucleotide and ATP simulations (C and D, respectively), these residues stably interact with complementary charge partners in tubulin and/or adjacent residues of kinesin.
Although the extent of complementary charge is less in the pore model, in this case the oligomer is stabilized by the beta barrel of the pore.
Although the extent of complementary charge is less in the pore model, in this case the oligomer is stabilized by the β-barrel of the pore.
Similar(50)
The domain rotation needed to bring complementary charges together would move these labeling sites farther apart.
The protein sequences exhibit a quasi-symmetrical pattern of complementary charges that can form extended ladders of salt bridges.
Enzyme hyperactivation using a complementary charged modulator/substrate pair has potential for enzyme applications in a wide range of research fields.
Peripheral patches with highly conserved complementary charges further stabilize the enzyme substrate complex by long-range electrostatic forces and may affect the orientation of the substrate.
Thus, the effects of predicted charge pairs depend on sequence context, and complementary charges at the edge positions rationalize only a fraction of the sequences that form stable, specific coiled coils.
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