Sentence examples for complementarity with a from inspiring English sources

One popular concept acts on the assumption that a bound ligand must exhibit perfect shape complementarity with a given binding pocket to achieve high affinity binding.

Also, several sequences of 20-25 nt located within Arabidopsis intergenic regions share perfect or near perfect complementarity with a variety of plant virus genomes, but have not been validated as miRNAs yet [ 27].

The biological significance of this finding is currently unknown, since the statistical significance of complementarity with a run of even 15-20 nucleotises is not high when the entire genome is scanned.

The following paragraph explains the proposed control mechanism in a scenario where a protein-coding mRNA shares complementarity with a processed antisense transcript; nonetheless, the mechanism could be relevant to other transcriptional units that produce complementary RNA.

MicroRNAs bound to RISC can down-regulate protein levels using at least two alternative pathways: 1) If the microRNA has imperfect complementarity with a matching sequence in the 3'UTR of its target mRNA, the microRNA-RISC complex can combine with the complement mRNA sequence and cause translational repression.

However, a 21-nucleotide double-stranded RNA sharing only partial complementarity with an mRNA is still competent to cause gene silencing via translational repression [ 8, 11].

This computational study gave reliable structural models for D2, 5-HT2A, and 5-HT7, whadh had overall structural complementarities with a salt bridge anchor at the center of the lurasidone molecule, but not for H1 and M1 owing to steric hindrance between the norbornane-2,3-dicarboximide and/or cyclohexane part of lurasidone and both receptors.

The Cas9 endonuclease from Streptococcus pyogenes type II CRISPR/Cas system can be engineered to produce targeted genome modification under the guidance of a synthetic single guide RNA (sgRNA) with simple base-pair complementarities with a target genomic DNA sequence.

The net result is a transition from a four-helix bundle with poor shape complementarity with LapG to a two-helix bundle and an overall shape that is able to accommodate LapG.

In this paper, we propose a smoothing-type algorithm for solving the nonlinear complementarity problem with a non-monotone line search.

For example, in this way we obtain the fastest known algorithm for the P-matrix generalized linear complementarity problem with a constant number of blocks.