Sentence examples for complementarity target from inspiring English sources

To identify miRNAs that regulate hPGRN expression, we used an miRNA target prediction program that considers complementarity, target site accessibility, and the extent of evolutionary conservation [28].

This might be one of several potential explanations as to why this relatively young snoRNA variant does not, despite the theoretical complementarity, target modification of G4980 in 28 S rRNA.

The former usually are located in intergenic regions and share only poor and incomplete complementarity with target sequences, which complicates computational target predictions.

Target prediction by TargetScan database is established on sequence complementarity to target sites with emphasis on perfect base-pairing in the seed region and on sequence conservation among species [88].

MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of complementarity of target messenger RNAs, resulting in transcriptional regulation and translational repression of target genes.

There are two classes of ncRNAs: one that includes antisense RNA and microRNA, and functions by sequence complementarity to target mRNA or DNA, whereas another functions independently of sequence complementarity by forming a functional 3D structure to target protein or macromolecules as an apparent equivalent to a protein.

They are incorporated into an RNA induced silencing complex (RISC) that binds to sites of variable complementarity in target messenger RNAs, triggering their degradation and/or repressing their translation [1].

The orientation protocol allowed us to identify 23 antisense RNAs that showed perfect complementarity with target mRNAs encoded from the same DNA locus (Figure 1F and 1G, for example).

Sequence complementarity among target, primers, and probe used in quantitation was also verified.

When an miRNA and an mRNA exhibit perfect complementarity, the target mRNA is cleaved by RISC.

MiRNAs reduce mRNA stability and/or translation due to full or partial sequence complementarity within target mRNAs.