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Use of distinct overhangs enables directional ligation based on sequence complementarity of one overhang with another, and their sequence is constant based on their position in the order of ligated modules.
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Thus, the second step of our strategy was either analysis of published data and selection of experimentally validated target mRNAs for a given miRNA or theoretical prediction of miRNA targets based on their complementarity, using one of the most popular web resources TargetScan [ 28].
The SCG is conceived as one key strategic way of helping ECDC address its mandate to foster comprehensiveness, coherence and complementarity of action on communicable diseases in Europe.
[ 2, 16, 30] We adopted a model which relies of the principle of complementarity, using the strengths of one method to enhance the other.
Complementarity is one of the most important principles of quantum physics [1].
In fact, this complementarity is one of the main motivations for attempting fMRI of epileptic activity, in addition to the more uniform spatial sensitivity than electrophysiological techniques.
One answer lies in the notion of complementarity: Having one product makes a person want another.
The analysis also shows their mutual complementarity: growth in the rate of one of the indicators is usually accompanied by a drop in the other.
Depending on the complementarity of the miRNA to its target, one miRNA may bind several regions on the same mRNA or on different mRNAs (Filipowicz et al, 2008).
Interdependency: This implies that the benefit of one decision is contingent on relative alignment or complementarity with other decisions made elsewhere in the company.
Robertson demonstrates that this earlier worldview can offer an alternative model of human-nonhuman complementarity, one premised neither on compulsory human exceptionalism nor on the simple reduction of one category to the other.
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