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If, indicating that there is no promising effect of the treatment in the complement, the trial will be continued with the subpopulation only (option B in Section 3.1).
Triangulation of social science studies within the ANRS 12249 TasP trial will provide comprehensive insights into the acceptability and feasibility of the TasP intervention package at individual, community, patient and health system level, to complement the trial's clinical and epidemiological outcomes.
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This process evaluation will complement the UMPIRE trial by using qualitative research methods to inform understanding of the complex interplay of factors that underpin trial outcomes.
Because the longer median survival of Asian patients with NSCLC could be a confounding effect in a global trial, INSPIRE (Stimuvax trial In Asian NSCLC Patients: stimulating Immune Response), was initiated in a solely East-Asian population to complement the START trial.
The Mac-SoLID trial enhances and complements the SoLID trial.
It is a very useful approach and complements the field trial approach.
The Mac-SoLID study enhances and complements the SoLID trial.
6– 9 In this therapy area, there is an established precedent of assessing the response to and safety of long-term treatment with GH and of supporting and complementing the clinical trial evidence base through registry tools.
With the animal metabolism study which has been run in parallel, these three studies were designed to complement the large mortality trials[ 11] which alongside existing data from previous NNVAS trials (conducted in Indonesia, Bangladesh, Nepal, India, Guinea-Bissau and Zimbabwe[ 5- 9, 42]) will provide definitive information in formulating global policy for this intervention.
Similarly, novel early-phase clinical trials of preoperative RT + targeted therapy or neoadjuvant hormonal therapy with baseline on-treatment biopsies for markers and gene signatures of radiosensitivity (the window of opportunity design) could complement the development of trials of stereotactic body RT to primary + neoadjuvant systemic therapy for limited-volume metastases in liver and bone.
The COMPLeMENT trial is a prospective, pragmatic RCT of printed, evidence-based educational material that incorporates a no-intervention control.
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