Exact(2)
In this study, we demonstrate that a P5CR-GFP fusion protein is localised exclusively in the cytosol and can fully complement the developmental defects of p5cr mutants.
To complement the developmental and genetic studies in P. pacificus, a genetic linkage map and a physical map have been generated and a whole genome sequencing draft of P. pacificus is available [ 15- 18].
Similar(58)
Interestingly, the N-terminus of SmMOB3 containing the conserved mob domain (pMob3N), also fully complemented the developmental defect of ∆Smmob3, while the C-terminus of SmMOB3 alone (pMob3C) did not complement the defect.
Firstly, we showed that RACK1B and RACK1C are likely in principle functionally equivalent to RACK1A, because overexpression of either RACK1B or RACK1C under the constitutive CaMV 35S promoter fully complemented the developmental defects of rack1a mutants.
We reasoned that if RACK1B and RACK1C are indeed functionally equivalent to RACK1A, one would expect that overexpression of RACK1B or RACK1C complements the developmental defects of rack1a mutants.
To address the question whether the overexpression of one of the β-CAs of S. macrospora can complement the severe developmental defects in the Δcas1/2 double mutant, we transformed this strain with overexpression constructs of cas1, cas2, cas3 and cas2-CTG.
The results of this study complement previous studies of the developmental toxicity of the type A brevetoxin brevetoxin-1 (PbTx-1), by illustrating in vivo the differing affinities of the two congeners for cardiac sodium channels.
The composition of the EST set used in these microarray experiments has previously been considered specifically with respect to the complement of developmental signalling pathway components [ 2, 3], but this paper is the first to examine broad scale changes in gene expression during development for any cnidarian.
AM, EMT and CC identified the histone complement, AM and MR performed the developmental expression profiles, PWTCJ and HGS performed the mass spectrometry, CC and CN assessed H2A.Z alternative splicing, AM, CC and EMT designed experiments and analyzed the data, AM and EMT wrote the manuscript.
These methods complement the experimental approaches of developmental biology and genetics, and can be expected to be especially fruitful in combination with them.
However, human α-synuclein does not completely replace mouse α-synuclein since the developmental reduction in the dopaminergic neurons is not complemented by human α-synuclein.
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