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Taken together, our previous data combined with data from the current study illustrate that gonadal secretions, but not sex chromosome complement, play a role in modulating responses to IAV infection.
Direct binding of autoantibodies to glomerular antigens is particularly relevant, and the site of complex formation, along with the capacity of deposited Ig to engage FcR and activate complement play important roles in disease expression.
Canine VL is considered to undergo chronic evolution, and therefore, these findings suggested that immunoglobulin and complement play no role in the pathogenesis of glomerulonephritis in infected dogs, at least in the apparently advanced stage in which the studied animals were examined.
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The Perron complement plays an important role in statistics, matrix theory, control theory, and so on (see [1 4]).
With the revelation that complement plays a crucial role in the pathogenesis of inflammatory tissue destruction, a great enthusiasm has evolved for specific complement inhibition as a novel treatment of human diseases [3, 5, 6, 38].
Without doubt, complement plays a role in the development of atherosclerosis.
Complement plays a central role in the innate immune system, providing an important defence against infection and immune complex disease.
In all these diseases, abnormal activation of complement plays an important role as initiator and amplifier of kidney damage [ 36– 36].
Complement plays a role in chemotaxis, opsonization and vascular permeability, and can be induced alongside acute phase responses [ 52].
This case supports the hypothesis that complement plays an important role in the development of stiffness of elastic arteries.
Complement plays a critical role as a chemoattractant for phagocytes and polymorphonuclear leukocytes and recruits these immune cells to the site of injury.
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