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The protein complement of the heart directly underpins its functional properties, including electrophysiology, contractility, susceptibility to disease, and response to pathological insults.
The intimate link between cardiac physiology and the protein complement of the heart makes the proteome a highly fertile ground for discovering biomarkers to predict disease susceptibility, assist diagnoses, or help to monitor responses to therapeutic interventions.
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Indeed CRP has been shown to be co-localized to these areas of the heart that are positive for complement deposits [10].
Likewise, a complement C5a receptor antagonist prevented cellular infiltration, fibrosis and stiffening of the heart in DOCA-salt hypertensive rats [ 23].
Heart disease, any disorder of the heart.
It refers to the electrophysiological activity of the heart.
The shots provoked a brief acceleration of the heart rate.
Birth defects of the heart.
But recent evidence suggests that the heart-protecting effects of HDL depend on a person's particular complement of the various forms of HDL, some of which are more beneficial than others.
Because of this limited data, observations using the ISO 7243 reference table complemented the heart rate data.
These data complement the paradigm identified in the heart of 3-day post-MI rats subjected to type I diabetes and further supports the premise that a diabetic milieu rather than a direct effect of streptozotocin compromised the neurogenic response of a subpopulation of cardiac resident nestin cells.
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