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The phosphorylation sites identified provide an immediate set of novel drug targets, and an analysis of the complement of sites provides a logic for the selection among potential treatments using multi-targeted kinase inhibitors or combinations of selective inhibitors.
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Consequently, this would imply that assignment of full complement of regulatory sites that act upon a single gene of interest can be seriously impeded by extreme site separation and this could in turn hinder attempts to associate disease causing non-coding mutations with their concerned gene bodies.
Even within a cell, the available complement of pTyr sites and locally available SH2 domain proteins may vary over the lifetime of a signal.
This season's complement of 14 site-specific installations, on view since mid-June, has had a couple of casualties, but the 12 remaining pieces are worth seeking out.
Mr. Jagger listened to the pitch, and then shot back, as he later recalled in an interview on SiriusXM radio, "You mean it's like Coachella for old people?" Mr. Jagger was intrigued, though, and thus was born Desert Trip, along with its stereotype as a boomer-ready version of a 21st-century pop festival, with a telegram-from-1969 telegram-from-1969 telegram-from-1969 on-site lineupes.
Very small BESs do exist and many functioning BESs do not contain the full complement of expression site associated genes (ESAGs).
Although very little is known about the consensus sequences for splicing of noncoding RNAs, it is possible that the reverse complement of the canonical sites in FMR1 are being recognized as non-canonical consensus sequences by the splicing machinery.
Additionally, a consensus ribosomal binding site (RBS) of highly expressed genes (identical to the complement of mRNA-binding site of the 16S rRNA [ 25]) was cloned upstream this restriction site.
This site is identical to the reverse complement of the ATF site in the dp5 promoter and is conserved in the rat, mouse and cow genes and only one nucleotide differs in the human trib3 gene.
Both Nkx2.5 and Prrx2 are homeodomain transcription factors, and the reverse complement of the Prrx2 site (TAATT) is contained within the Nkx2.5 site.
Other minor complementation groups failed to complement unlinked sites of either the ATPalpha DTS1R1 or the ATPalpha DTS2R3 chromosome (but not both).
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