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Mr. Lhota suggested that if subway service could be partially restored in less-affected areas of the system — the Manhattan and Brooklyn legs of the No. 4 train, for instance, but not the tunnel that connects them — buses may be rerouted to complement functioning stretches.
The mechanism of diabetes-dependent C3 incorporation into fibrin clots with concomitant effects on clot characteristics adds to our knowledge of the broad aspects of complement functioning in type 1 and, potentially also, type 2 diabetes, and may in due course be extended to related disorders, including obesity and NAFLD.
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The high frequency of MBL deficiency and functional defects [5], [9] makes MBL mediated complement function assays unsuitable for elucidation of deficiencies downstream of MBL itself.
The functional diversity provided by disordered regions is believed to complement functions of ordered protein regions by protein-protein interactions [41].
An overview of complement function is provided in order to understand the underlying genomic landscape.
To exclude that complement activity played a role, whole blood circulation experiments were also conducted at 10 U/ml of soluble heparin, a concentration which inhibited complement function.
Complement functions are similar among many species, and corresponding components from one species can carry out the same functions when introduced into another species.
Petry, F., Botto, M., Holtappels, R., Walport, M. J. & Loos, M. Reconstitution of the complement function in C1q-deficient (C1qa−/−) mice with wild-type bone marrow cells.
To preserve complement function while prevent clotting, blood from healthy donors was treated with a low dose (1 U/ml) of soluble heparin and was kept in rotation in a Corline heparin inner surface tubing system.
The jawless fishes have complement components corresponding only to the later-acting (i.e., cytolytic, or cell-killing) aspects of complement function, but all higher vertebrates have components similar to the complete complement system of mammals.
One of these, the staphylococcal complement inhibitor (SCIN), acts at the level of the C3 convertase (C3bBb) and impairs downstream complement function by trapping the convertase in a stable but inactive state.
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