Exact(8)
Since it is able to complement defects of S. cerevisiae gcs1Δ cells, AGE3 is probably the functional ortholog of the S. cerevisiae GCS1 gene.
Non-Stx diarrhoea commonly triggers aHUS in individuals with underlying complement defects.
A focussed genetic analysis in search of mutations associated with complement defects or proteinuric podocytopathies was negative.
Complement defects, and in particular low levels of MBL, have also been related to the development of CNPA [ 27].
Human Hsp90 was able to complement defects caused by deletion of its counterpart in yeast cells (Picard et al. 1990; Millson et al. 2007).
Arabidopsis Mei2- like 1 (AML1), the first member of this family to be described, was isolated in a screen for plant cDNAs whose expression could complement defects in the fission yeast meiosis signaling pathway [ 22].
Similar(52)
In those with an underlying complement defect, reversal of the haematological manifestations is expected, and in addition, some dialysis-dependant patients may be able to stop dialysis.
Of these, 13 PEX genes functionally complement the defects in peroxisome assembly of all the known complementation groups of the PBDs (Shimozawa et al., 2005; Steinberg et al., 2006).
This is because the renal allograft will usually correct the recipient's membrane-bound CD46 defect, whereas there is a high rate of recurrent disease post transplant in those individuals with serum complement protein defects.
Thus, gas4p is able to fully complement the defects of gas1Δ cells.
Interestingly, depletion of PML can partially complement the defects of an ICP0-null mutant virus [33].
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