Exact(1)
In those with an underlying complement defect, reversal of the haematological manifestations is expected, and in addition, some dialysis-dependant patients may be able to stop dialysis.
Similar(59)
Since it is able to complement defects of S. cerevisiae gcs1Δ cells, AGE3 is probably the functional ortholog of the S. cerevisiae GCS1 gene.
Non-Stx diarrhoea commonly triggers aHUS in individuals with underlying complement defects.
A focussed genetic analysis in search of mutations associated with complement defects or proteinuric podocytopathies was negative.
Complement defects, and in particular low levels of MBL, have also been related to the development of CNPA [ 27].
Human Hsp90 was able to complement defects caused by deletion of its counterpart in yeast cells (Picard et al. 1990; Millson et al. 2007).
Arabidopsis Mei2- like 1 (AML1), the first member of this family to be described, was isolated in a screen for plant cDNAs whose expression could complement defects in the fission yeast meiosis signaling pathway [ 22].
Marked susceptibility to meningococcal disease is seen in individuals with rare complement defects (especially loss of components of the terminal pathway, which is necessary for bacteriolysis and not opsonphagocytosis), those receiving C5 inhibitors (i.e. eculizumab), and inherited defects of the AP (i.e. properdin and factor D deficiencies).
In SLE patients, several abnormalities have been found that can result in decreased clearance of apoptotic cells and the release of blebs and chromatin, such as complement defects [ 17], low levels of the pentraxin C-reactive protein [ 18], and reduced levels and activity of DNase I in serum [ 19].
In order to complement this defect, an enhanced version for the middle-domain mobility management is designed in this paper.
It is still possible that manBcore (BMEII0899) could internally complement the defect in the wbk manB mutant.
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