Sentence examples for complement caused from inspiring English sources

Defects in adequate inhibition of complement caused by inherited or acquired deficiencies of complement inhibitors could thus be involved in development and exacerbations of SLE nephritis.

In general, complement causes damage by three mechanisms [4].

Activation of complement causes recruitment of immune cells; opsonization of coated cells; and direct killing of affected cells through a membrane attack complex (MAC).

When a good insight is gained as to how complement causes diseases, it will help provide a good approach in designing the appropriate treatment that will have a specific target to provide the needed cure.

In these conditions, the anterior midgut epithelium was injured by the complement, causing cell death.

In cultured cells, AQP4-IgG binds extracellular conformational domains of AQP4 and activates complement, causing cell lysis [ 4].

DM is a microangiopathy affecting the skin and muscle, in which the early activation and deposition of complement causes the lysis of endomysial capillaries and muscle ischemia.

Dysregulation of the alternative pathway (AP) of complement causes a spectrum of kidney diseases ranging from atypical hemolytic uremic syndrome (aHUS) to C3 glomerulopathy (C3G) [ 1– 3].

In preliminary experiments, this effect could be decreased by more than 50% by heating the sera to 56°C for 30 min, suggesting heat-labile factors (maybe complement) cause the cytotoxicity.

It is due to uncontrolled activation of the alternative pathway of the complement system, caused by genetic mutation in complement genes (>60% of patients), anti-FH antibodies (5 6% of patients) and other mutations not related to the complement system recently described, as DKGE gene mutation or methylmalonic aciduria.

Therefore, we hypothesize that opsonization dysfunction of the complement system caused by MBL gene mutation is involved in the immune response to infection.