Recently developed CD20 mAbs, engineered to form hexamers on binding to cells, react with B-cells in serum, chelate C1q, and then activate complement and promote cell killing considerably more effectively than their wild-type precursors.
Lupus nephritis results from glomerular deposition of immunoglobulins, which in turn activate complement and promote inflammation.
In response to injury or disease, the same astrocytes express a number of proteins that compromise the integrity of blood-retinal barrier, up-regulate the expression of various genes related to cytokines, chemokines, and the complement cascade, and promote retinal degeneration [27], [28].
A β can also activate the complement system and promote the formation of immune complexes, which attack the neurons that are malnutritioned or damaged resulting in decomposition of the cell membrane and cell death.
The porins of N. gonorrhoea stimulate the host immune system to produce specific antibodies which activate the complement system and promote phagocytosis to eliminate the invading gonococci [ 9, 42].
These complexes activate the classical complement pathway, acting as opsonins and promoting phagocytosis.
4: Demonstration projects can complement advocacy efforts - Such demonstration project can complement advocacy efforts and promote quick scale of pilot models, through leveraging public and external funding.
PSVI was established to complement wider UK government work by raising awareness and promoting international co-operation.
"My advice to students is to always ensure consistency across all of their applications and sites, so that they complement each other and promote the same key messages," says Caroline Thorley.
The complement system plays an important role in host defense against microorganisms and promoting the adaptive immune response [17].
