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First, we compiled training sets of known enhancers expressed in different cardiac cell subtypes.
In order to build classifiers, i.e. computational models that can discriminate cardiac cell type-specific enhancers from other DNA sequences, we first compiled training sets of enhancers with activity in the different cells of the Drosophila heart (Fig. 1).
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Nancy Whitaker (University of Adelaide) assisted in compiling training materials and administering the questionnaires.
We compiled five training sets of highly variable morphologies of mammalian teeth from the MorphoBrowser database.
Here, we compiled a training gene list that included 10 well-known melanoma genes (BRAF, NRAS, CDK4, MITF, PTEN, CDKN2A, TP53, KIT, GNAQ and GNA11).
The manual contains four units with activities and compiles training materials on AIDS prevention from China and abroad.
Work is also underway to improve routine paper-based MOH reports compiled by trained data coordinators who partner with district supervisors.
An R-script was compiled to train the SVMs and subsequently classify and rank all the obtained sORFs according to coding probability.
After compiling the training set with this procedure for every structural superclass, the SVR is applied to each training set as described above.
The probabilities in Figure 1 are based on a likelihood ratio between the two population groups sampled to compile the training sets, so the possibility of an individual having ancestry outside of Europe or North Africa, for example from sub-Saharan Africa, are not precluded by any of the values obtained.
In this section, we detail the data used in our empirical evaluation, including development of the ground truth and the method for compiling separate training and test sets.
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