Attempts to find common characteristics for protein-protein recognition sites have only been moderately successful, since the average binding epitope of a large compilation of protein-protein interfaces is almost indistinguishable from a regular protein surface [ 51].
We also improved performance against the original MS analysis in ROC and precision recall plots, using our compilation of protein reference sets, showing 10 24% increase in ROC-AUC.
Performing a similar analysis on a compilation of protein-protein interactions derived from multiple high-throughput sources (the Interologous Interaction Database - I2D) in with the Edge Weight (K I2D ) is defined as the number of protein-protein interaction databases containing a given revealed a similar distribution.
There are two recent independent reports on the identification and prioritization of candidate disease genes in general as well as specific to primary immunodeficiencies by integrating functional annotations from gene ontology and compilation of protein interaction network data sets from BIND, BioGRID and HPRD.
In order to be on the more conservative side of the human genome annotation errors, we retrieved from public databases the same compilation of human protein sequences (20,259 unique proteins) that were used in the recent cancer genome sequencing projects [ 48].
References. 1. Bietz S, Rarey M. SIENA: Efficient compilation of selective protein binding site ensembles.
HAPPI is by far the most comprehensive public compilation of human protein interaction information.
The HAPPI database aims to become the most comprehensive public compilation of human protein interaction information.
HAPPI is by far the most comprehensive public compilation of human protein interaction data that come with a unified framework of interaction data reliability scores.
The domain interaction network thus obtained comprises 1, 566 domains which are embedded in 2, 767 interactions that score E ij ≥ 3. We utilized a large scale compilation of yeast protein interactions.
