Exact(8)
10.7554/eLife.05701.004 Figure 2. Non-self competitor bacteria stimulate expression and activity of the H1-T6SS.
Anti-bacterial T6SSs can inject multiple distinct anti-bacterial toxins into target cells, causing efficient killing of competitor bacteria.
The two competitor bacteria were added to all tubes at calculated concentrations of 1.2 × 107 cfu/g for E. coli DJOec1 and 5.1 × 107 for Clostridium difficile DJOcd1.
The T6SS is an impressively effective weapon against competitor bacteria, with a rapid rate of discharge of its deadly cargo into adjacent cells.
Variable toxin domains are found at the C-terminus of CdiA (CdiACt), which mediate contact-dependent growth inhibition of competitor bacteria.
It is now clear that the T6SS can be also used to target other, competitor, bacteria and is thus likely to play an important role in polymicrobial infections.
Similar(52)
For example, it contains genes that secrete substances that kill competitors, like harmful bacteria and fungi, using the sort of weaponry usually seen in pathogens like tuberculosis and diphtheria.
Macro-bacteria of Beggiatoacea family are considered to be the most direct competitors to cable bacteria at the interface of oxic anoxic zone of marine sediments (see Nielsen and Risgaard-Petersen, 2015).
It has fifty-two fewer genes than its nearest natural competitor, M. genitalium, a bacterium that infects the human urinary and genital tracts, but is still well above the theoretical lowest point.
Deployment of the T6SS represents an efficient and widespread means by which bacteria attack competitors or interact with host organisms and may be triggered by contact from an attacking neighbor cell as a defensive strategy.
One novel application is the use of engineered bacteria as competitors and predators of cancer cells in the hypoxic environments they create inside tumors, where other agents lose effectiveness (Dang et al. 2001).
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